ALPHA-NEOENDORPHIN (1-5) AMIDE
LEU-ENKEPHALIN AMIDE
CAS: 60117-24-0
Molecular Formula: C28H38N6O6
ALPHA-NEOENDORPHIN (1-5) AMIDE - Names and Identifiers
ALPHA-NEOENDORPHIN (1-5) AMIDE - Physico-chemical Properties
| Molecular Formula | C28H38N6O6 |
| Molar Mass | 554.64 |
| Density | 1.254±0.06 g/cm3(Predicted) |
| Melting Point | 123-126 °C |
| Boling Point | 1012.8±65.0 °C(Predicted) |
| pKa | 9.97±0.15(Predicted) |
| Storage Condition | −20°C |
| In vitro study | [Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC 50 value of 2.1 nM. |
| In vivo study | Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05). |
ALPHA-NEOENDORPHIN (1-5) AMIDE - Risk and Safety
| WGK Germany | 3 |
ALPHA-NEOENDORPHIN (1-5) AMIDE - Reference Information
| biological activity | [Leu5]-Enkephalin, amide is a delta opioid receptor (opioid receptor) agonist. |
| target | δ opioid receptor |
| in vitro research | [Leu5]-Enkephalin concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC 50 value of 2.1 nM. |
| in vivo studies | levels of [leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; P <0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; P <0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05). |
Last Update：2024-04-09 20:45:29
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View History
ALPHA-NEOENDORPHIN (1-5) AMIDE
(3-((4-(叔-丁氧基羰基)哌嗪-1-基)甲基)苯基)硼酸
(1-METHYLCYCLOPENTYL)METHANESULFONYL CHLORIDE
7-氨基-3-甲氧基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸
GEOGRAPHUTOXIN II (GTXII)
CericPerchlorateSolution
METHYL 2-((2-NAPHTHYLSULFONYL)AMINO)ACETATE
TRIBUTYL[2,4-DICHLOROBENZYL]PHOSPHONIUM CHLORIDE
CALCIUM LACTOBIONATE
2-(3-异丙氧芬基)喹啉-4-甲酰氯
(3-((4-(叔-丁氧基羰基)哌嗪-1-基)甲基)苯基)硼酸
(1-METHYLCYCLOPENTYL)METHANESULFONYL CHLORIDE
7-氨基-3-甲氧基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸
GEOGRAPHUTOXIN II (GTXII)
CericPerchlorateSolution
METHYL 2-((2-NAPHTHYLSULFONYL)AMINO)ACETATE
TRIBUTYL[2,4-DICHLOROBENZYL]PHOSPHONIUM CHLORIDE
CALCIUM LACTOBIONATE
2-(3-异丙氧芬基)喹啉-4-甲酰氯